Maria J. Redondo, MD, PhD, MPH

Personal Statement

My philosophy of care is to provide each child or adolescent with the most advanced medical care, in an individualized and comprehensive manner, to ensure their health and wellbeing. I promote shared decision making with the youth, in an age-appropriate manner, and their family.

My clinical activity focuses in the care of children with diabetes, including type 1, type 2 and other types of diabetes.

The overall goal of my research is the prevention of diabetes and its progression. I am interested in discovering the genetic and environmental causes of diabetes that can be leveraged for prevention and treatment. I also work to understand how to optimize clinical outcomes in pediatric diabetes.

Active Funded Research Projects:

- Type 1 diabetes genetic risk scores for the diagnosis of diabetes type in children of diverse racial and ethnic background (NIH NIDDK 1R01DK124395-01A1, PI Redondo)

- Type 1 diabetes genetic risk score in TrialNet (NIH NIDDK 1 R01 DK121843-01, PI Redondo)

- TrialNet Affiliate Clinical Center (NIH, site PI Tosur, Redondo’s role: Co-investigator)

- Center for Identification and Study of Individuals with Atypical Diabetes Mellitus (U54). Rare and Atypical Diabetes Network (RADIANT) (NIH 1 U54 DK118638, site PI Redondo)

- Immune Function and the Progression of Type 1 Diabetes (NIH NIAID P01 AI042288-25; PI Brusko; Redondo’s role: Site PI)

- Enhancement of biomarkers of type 1 diabetes (NIH 2 R01 DK112311-15A1, PI Pietropaolo; Redondo: Co-investigator)

- Diabetes-Docs: Physician Scientist Career Development Program (NIH NIDDK National K12; MPI: DiMeglio, Maahs; Redondo’s role: Program Scientific Review Committee)

- Addressing Social Needs and Behavioral Health Early in the Type 1 Diabetes Course to Mitigate Inequitable Health Outcomes among Socioeconomically Disadvantaged Minority Youth (BCM, PI Butler; Redondo: Co-investigator)

- Emergency Funding to Support Underserved T1D Populations Impacted by the COVID-19 Pandemic (Helmsley Charitable Trust, PI Redondo)

Clinical Interests

· Diabetes (type 1 diabetes, atypical diabetes, type 2 diabetes, monogenic diabetes, etc.)

Education

Organizations

* Texas Children’s Hospital physicians’ licenses and credentials are reviewed prior to practicing at any of our facilities. Sections titled From the Doctor, Professional Organizations and Publications were provided by the physician’s office and were not verified by Texas Children’s Hospital.

Research interests

· Prediction and prevention of type 1 diabetes

· Genetics of type 1 diabetes

· Rare and atypical diabetes

· Heterogeneity of diabetes

Redondo MJ, Gignoux CR, Dabelea D, Hagopian WA, Onengut-Gumuscu S, Oram RA, Rich SS. Type 1 diabetes in diverse ancestries and the use of genetic risk scores. Lancet Diabetes Endocrinol. 2022 Aug;10(8):597-608. doi: 10.1016/S2213-8587(22)00159-0. Epub 2022 Jun 17.PMID: 35724677  

Redondo MJ, Warnock MV, Libman IM, Bocchino LE, Cuthbertson D, Geyer S, Pugliese A, Steck AK, Evans-Molina C, Becker D, Sosenko JM, Bacha F; Type 1 Diabetes TrialNet Study Group. TCF7L2 Genetic Variants Do Not Influence Insulin Sensitivity or Secretion Indices in Autoantibody-Positive Individuals at Risk for Type 1 Diabetes. Diabetes Care. 2021 Sep;44(9):2039-2044. doi: 10.2337/dc21-0531. Epub 2021 Jul 29.PMID: 34326068 

Redondo MJ, Evans-Molina C, Steck AK, Atkinson MA, Sosenko J. The influence of type 2 diabetes-associated factors on type 1 diabetes. Diabetes Care 2019 Aug;42(8):1357-1364. PMID: 31167894 

Redondo MJ, Steck AK, Sosenko J, Anderson M, Antinozzi P, Michels A, Wentworth JM, Atkinson MA, Pugliese A, Geyer S; Type 1 Diabetes TrialNet Study Group. Transcription Factor 7-Like 2 (TCF7L2) Gene Polymorphism and Progression From Single to Multiple Autoantibody Positivity in Individuals at Risk for Type 1 Diabetes. Diabetes Care 2018 Dec;41(12):2480-2486. PMID: 30275285. 

Redondo MJ, Geyer S, Steck AK, Sharp S, Wentworth JM, Weedon MN, Antinozzi P, Sosenko J, Atkinson M, Pugliese A, Oram RA. A type 1 diabetes genetic risk score predicts progression of islet autoimmunity and development of type 1 diabetes in individuals at risk. Diabetes Care 2018 Sep;41(9):1887-1894. PMID: 30002199. 

Redondo MJ, Libman I, Cheng P, Kollman C, Tosur M, Gal RL, Bacha F, Klingensmith GJ, Clements M; Pediatric Diabetes Consortium. Racial/Ethnic Minority Youth With Recent-Onset Type 1 Diabetes Have Poor Prognostic Factors. Diabetes Care 2018 May;41(5):1017-1024. PMID: 29496742. 

Redondo MJ, Geyer S, Steck AK, Sosenko J, Anderson M, Antinozzi P, Michels A, Wentworth J, Xu P, Pugliese A, and the Type 1 Diabetes TrialNet Study Group. TCF7L2 Genetic Variants Contribute to Phenotypic Heterogeneity of Type 1 Diabetes. Diabetes Care 2018 Feb;41(2):311-317. PMID: 29025879 

View PubMed Publications