Michael F. Wangler, MD

Dr. Michael Wangler is a board-certified medical geneticist and human genetics researcher at Texas Children’s Neurofibromatosis Clinic and an Associate Professor of Molecular and Human Genetics at Baylor College of Medicine. His clinical expertise includes peroxisomal disorders, a rare group of pediatric brain disorders resulting from a particular defect in body chemistry. He also specializes in disorders of intestinal hypomotility, which represent a group of rare, difficult-to-treat diseases; autism spectrum disorders; and the genetic basis of neurological disorders.

When he is not conducting research or in clinic, Dr. Wangler enjoys attending sporting events with his children.

Personal Statement

The care of children, particularly those with genetic disorders, is a very important privilege that requires training, dedication and a team approach. I feel, like many who trained under him that the late Ralph Feigin, former Pediatrician-in-Chief, gave us a roadmap for what we do at Baylor and Texas Children's in navigating the future of medicine and the challenges we face in the post-genomic era. I am committed to providing the best care for my patients with the most powerful technology and the most current knowledge, but to remain practical and to provide it in a manner that includes compassion and humanity in medical care. Our department also provides a strong mingling of research and clinical care, and the importance of success in research cannot be underestimated with so many genetic disorders that remain untreatable or for which the diagnostic process is not optimal.

Michael F. Wangler Lab

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* Texas Children’s Hospital physicians’ licenses and credentials are reviewed prior to practicing at any of our facilities. Sections titled From the Doctor, Professional Organizations and Publications were provided by the physician’s office and were not verified by Texas Children’s Hospital.

Wangler MF, Leskoc B, Dahalc R, Jangamb S, Bhadane P, Wilsona T, McPherona M, and Miller MJ. Dicarboxylic Acylcarnitine Biomarkers in Peroxisome Biogenesis Disorders. Available on SSRN https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4429049

Jangam S, Briere L, Jay K, Andrews J, Walker M, High F, Yamamoto S, Sweetser D, Wangler MF*. A de novo missense variant in EZH1 associated with developmental delay exhibits functional deficits in Drosophila melanogaster. Genetics. Available on MedRxiv https://doi.org/10.1101/2023.01.31.23285113

Andrews JC, Mok JW, Kanca O, Jangam S, Tifft C, Macnamara EF, Russell BE, Wang LK; Undiagnosed Diseases Network; Nelson SF, Bellen HJ, Yamamoto S, Malicdan MCV, Wangler MF* (2023).De Novo Variants in MRTFB have gain of function activity in Drosophila and are associated with a novel neurodevelopmental phenotype with dysmorphic features. Genet Med. ;100833. doi: 10.1016/j.gim.2023.100833. PMID: 37013900

Lyons-Warren AM, Wangler MF, Wan YW (2022). Cluster Analysis of Short Sensory Profile Data Reveals Sensory-Based Subgroups in Autism Spectrum Disorder. Int J Mol Sci. 23(21):13030. doi: 10.3390/ijms232113030. PMID: 36361815

Huang Y, Lemire G, Briere LC, Liu F, Wessels MW, Wang X, Osmond M, Kanca O, Lu S, High FA, Walker MA, Rodan LH; Undiagnosed Diseases Network; Care4Rare Canada Consortium, Wangler MF, Yamamoto S, Kernohan KD, Sweetser DA, Boycott KM, Bellen HJ (2022). The recurrent de novo c.2011C>T missense variant in MTSS2 causes syndromic intellectual disability. Am J Hum Genet. 109(11):2092. doi: 10.1016/j.ajhg.2022.10.001 PMID: 36332614

Lu S, Ma M, Mao X, Bacino CA, Jankovic J, Sutton VR, Bartley JA, Wang X, Rosenfeld JA, Beleza-Meireles A, Chauhan J, Pan X, Li M, Liu P, Prescott K, Amin S, Davies G, Wangler MF, Dai Y, Bellen HJ (2022). De novo variants in FRMD5 are associated with developmental delay, intellectual disability, ataxia, and abnormalities of eye movement. Am J Hum Genet. 109(10):1932-1943. doi: 10.1016/j.ajhg.2022.09.005 PMID: 36206744

Gofin Y, Zhao X, Gerard A, Scaglia F, Wangler MF, Schrier Vergano SA, Scott DA (2022). Evidence for an association between Coffin‐Siris syndrome and congenital diaphragmatic hernia. Am J Med Genet A. 188(9):2718-2723. doi: 10.1002/ajmg.a.62889. Epub 2022 Jul 7. PMID: 35796094

VIICTR Publications

PubMed Publications 

Google Scholar Publications